HORDB

ID: hor004588
Uniprot ID: P34032
Protein name: Hematopoietic system regulatory peptide
Gene name: TMSB4
Organism: Oryctolagus cuniculus (Rabbit)
Family: Thymosin beta family
Source: animal
Expression: Originally found in thymus but it is widely distributed in many tissues.
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Inhibits the entry of hematopoietic pluripotent stem cells into the S-phase
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004588_AF2.pdb

hor004588_ESM.pdb

Mass:	48317	Formula:	C18H31N5O7
Absent amino acids:	CEFGHILMNQRSTVWY	Common amino acids:	ADKP
pI:	6.34	Basic residues:	1
Polar residues:	0	Hydrophobic residues:	1
Hydrophobicity:	-180	Boman Index:	-1246
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	25
Instability Index:	-5380	Extinction Coefficient cystines:	0
Absorbance 280nm:	0